Krita 5.0 fixed an issue with text size in documents.Krita files (.kra) and krita brush preset files (.kpp) created with Krita 5.0 are not guaranteed to be compatible with Krita 4!.Krita 5 can no longer load vector layers created in Krita 3 and older.
After using Krita 5, going back to Krita 4 might cause Krita 4 to show duplicate resources. The way Krita 5 keeps a version history for resources that are edited by the user is not compatible with Krita 4.Krita 5 will be slower starting on the first run, quicker on subsequent runs. Krita no longer loads all brushes, patterns, gradients and so on start-up, but caches the information during the first run. Krita 5 has a completely new resource system.